COMPLEMENT ACTIVITY MODULATORS Russian patent published in 2020 - IPC A61K38/10 A61K47/02 A61P7/00 A61M5/00 

FIELD: medicine.

SUBSTANCE: group of inventions refers to compounds which can be used as complementarity activity modulators. Disclosed is a pharmaceutical composition for inhibiting activation of a complement component C5, comprising a C5 inhibitor polypeptide, having basic amino acid sequence SEQ ID NO: 1, and a pharmaceutically acceptable excipient, wherein the pharmaceutically acceptable excipient includes sodium chloride in concentration of 25 to 100 mM and sodium phosphate in concentration of 10 to 100 mM. Also disclosed are methods of inhibiting haemolysis in a patient and treating paroxysmal nocturnal hemoglobinuria using said composition, as well as a kit and an autoinjector device for inhibiting haemolysis, comprising said composition.

EFFECT: group of inventions enables selective blocking of complement-mediated cell destruction.

41 cl, 13 dwg, 18 tbl, 15 ex