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2 734 143

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IPC

A61K31/664(2006-01-01)

A61K36/68(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2020109475, 2020-03-04

(24)

Start date

2020-03-04

(22)

Actual filing date

2020-03-04

(45)

Published

2020-10-13

(72)

Inventor

Mylnikov Artem MikhajlovichNavolokin Nikita AleksandrovichMudrak Dmitrij AndreevichMaslyakova Galina NikiforovnaPolukonova Natalya VladimirovnaBucharskaya Alla BorisovnaNemolyaeva Elena KonstantinovnaKondrateva Darya Antonovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Meditsinskij Universitet Imeni V.I. Razumovskogo" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Vo Saratovskij Gmu Im. V.I. Razumovskogo Minzdrava Rossii)

METHOD OF COMBINED LIVER CANCER PC-1 THERAPY IN EXPERIMENT Russian patent published in 2020 - IPC A61K31/664 A61K36/68 A61P35/00

Abstract RU 2734143 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to experimental medicine and oncology, and can be used for combined therapy of liver cancer PC-1 in experiment. Method involves the daily introduction of cyclophosphamide in dose of 5 mg/kg for 3 weeks. Not earlier than 30 minutes later and not later than 45 minutes from the administration of cyclophosphamide, intraperitoneal introduction of a solution of gratiole extract daily in dose of 110 mg/kg.

EFFECT: use of the invention enables to potentiate anticancer effects of said substances in 2_6 times compared to separate use of cyclophosphamide, as well as a favorable effect on the body of laboratory animals with tumor, promotes body weight gain, prevents development of cachexia due to reduced toxicity by gratiole extract used in combination of cyclophosphamide, and reduced toxic effect of disintegration and tumor necrosis.

1 cl, 1 ex, 5 dwg

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RU 2 734 143 C1

Authors

Mylnikov Artem Mikhajlovich

Navolokin Nikita Aleksandrovich

Mudrak Dmitrij Andreevich

Maslyakova Galina Nikiforovna

Polukonova Natalya Vladimirovna

Bucharskaya Alla Borisovna

Nemolyaeva Elena Konstantinovna

Kondrateva Darya Antonovna

Dates

2020-10-13—Published

2020-03-04—Filed