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RU

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2 825 825

(13)

C1

(51)

IPC

G09B23/28(2006-01-01)

A61K33/243(2019-01-01)

A61K36/26(2006-01-01)

A61P35/04(2006-01-01)

(21) (22)

Application

2023135194, 2023-12-25

(24)

Start date

2023-12-25

(22)

Actual filing date

2023-12-25

(45)

Published

2024-08-30

(72)

Inventor

Filonova Mariya VasilevnaFedorova Elena PavlovnaRybalkina Olga YurevnaKotlovskaya Larisa YurevnaChurin Aleksej AleksandrovichZueva Elena PetrovnaUdut Vladimir Vasilevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Natsionalnyj Issledovatelskij Meditsinskij Tsentr Rossijskoj Akademii Nauk" Nimts)

METHOD FOR ENHANCING ANTIMETASTATIC ACTION OF CISPLATIN AND REDUCING ITS SIDE EFFECT ON HAEMOSTASIS SYSTEM Russian patent published in 2024 - IPC G09B23/28 A61K33/243 A61K36/26 A61P35/04 

Abstract RU 2825825 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, more specifically to oncology and haemostaseology, and can be used to enhance the antimetastatic action of cisplatin and reduce its side effect on the haemostasis system. C57BL/6 female mice with transplanted Lewis lung carcinoma with a single intraperitoneal administration of cisplatin in dose of 9 mg/kg on 10th day after tumour transplantation, daily from 16th to 19th day extract is administered intragastrically, obtained from cell culture Conium maculatum L., in dose of 30 mg/kg. Main indicators of metastasis and characteristics of haemostasis are assessed on 20th day after tumour grafting.

EFFECT: invention provides reducing the number and area of lung metastases, as well as significant changes in the parameters of the haemostasis system.

1 cl, 4 dwg, 1 tbl, 1 ex

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RU 2 825 825 C1

Authors

Filonova Mariya Vasilevna

Fedorova Elena Pavlovna

Rybalkina Olga Yurevna

Kotlovskaya Larisa Yurevna

Churin Aleksej Aleksandrovich

Zueva Elena Petrovna

Udut Vladimir Vasilevich

Dates

2024-08-30—Published

2023-12-25—Filed

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