LIPOSOMAL COMPOSITION AND PHARMACEUTICAL COMPOSITION Russian patent published in 2020 - IPC A61K9/127 A61K31/704 A61K47/04 A61K47/24 A61K47/28 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine, specifically to a liposomal composition for encapsulating a medicament, comprising: liposomes, each having an internal aqueous phase, and an aqueous solution which forms an external aqueous phase and in which liposomes are dispersed, wherein the liposome comprises a hydrophilic polymer-modified diacylphosphatidylethanolamine; dihydrosfingomyelin; and cholesterols; wherein each composition liposome encapsulates a drug; wherein the hydrophilic polymer-modified diacylphosphatidylethanolamine is polyethylene glycol or methoxypolyethylene glycol-modified diacylphosphatidylethanolamine; wherein dihydrosfingomyelin is dihydrosphingomyelin having a long chain alkyl group containing 16 carbon atoms and a long-chain alkyl group containing 18 carbon atoms; where drug represents an anticancer drug; where internal aqueous phase contains ammonium sulphate, and the molar ratio of sulphate ions in the internal aqueous phase to the sum of the drug in the internal aqueous phase and in the external aqueous phase is 0.36 or more, and also relates to a method of treating cancer.

EFFECT: group of inventions enables to obtain a composition which exhibits high AUC values.

16 cl, 6 dwg, 7 tbl