LONG-ACTING CONTROLLED RELEASE LIPOSOMAL COMPOSITION AND METHOD FOR PRODUCING IT Russian patent published in 2015 - IPC A61K9/127 A61K47/24 A61K47/28 A61K31/445 A61K31/452 A61J1/06 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to pharmaceutics. What is described is a liposomal composition produced by mixing a water-soluble organic solution with a solution of first aqueous phase, and producing an emulsion. The water-soluble organic solution contains phospholipid and cholesterol. That is followed by replacing an outer emulsion with a solution representing a second aqueous phase. That makes produce an ion gradient between the aqueous phase of the inside and that of the outside of a liposomal membrane. The produced liposome is characterised by an average particle diameter in terms of an outer diameter making from 2.5 mcm to 12 mcm, and a 12-35-layer structure. What is described is a prolonged- and controlled-release liposomal preparation containing a therapeutic agent, as well as a kit of the prolonged- and controlled-release liposomal preparation.

EFFECT: controlled release with the effective concentration of the medicinal product maintained for four days.

6 cl, 6 dwg, 11 tbl, 18 ex