FIELD: chemistry.
SUBSTANCE: invention relates to a compound of general formula II, in which ring A is selected from rings A-1, A-2 and A-3, having structures: 
, where wavy line, denoted 1, indicates point of connection of ring A to ring B, and corrugated line, denoted 2, indicates point of connection of ring A to W; X is N or CH; Y is H or F; R1 is H; ring B is selected from rings B-1, having the structure: 
, where wavy line, denoted by 3, indicates point of connection to ring A, and corrugated line, denoted by 4, indicates point of attachment to pyrazolo[1,5-a]pyrimidine ring of formula II; W is O, NH or CH2, wherein when ring A is A-2, W is CH2; m is 0 or 1; D is carbon, R2 and R2a are independently H or (1–3 C)alkyl, and R3 and R3a are independently H or (1–3 C)alkyl, P1 is H or a group protecting the carboxyl group; and R5 and R6 independently are H.
EFFECT: obtaining novel compounds of general formula II, which are used as starting compounds for producing macrocyclic compounds which are Trk kinase inhibitors.
13 cl, 1 tbl, 45 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | 2011 |
|
RU2594742C2 |
| SUBSTITUTED COMPOUNDS OF PYRAZOLE[1,5-a]PYRIMIDINE AS TRK KINASE INHIBITORS | 2010 |
|
RU2584157C2 |
| TRIAZOLOPYRINE COMPOUNDS AS KINASE INHIBITORS PIM | 2012 |
|
RU2598846C2 |
| PHENOXYMETHYL DERIVATIVES | 2016 |
|
RU2746481C1 |
| PYRROLIDINYL UREA AND PYRROLIDINYL THIOUREA COMPOUNDS AS TRKA KINASE INHIBITORS | 2012 |
|
RU2606131C2 |
| HETEROCYCLIC COMPOUNDS AS TRK INHIBITORS | 2019 |
|
RU2803817C2 |
| COMPOUNDS OF SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZOL [1,2-a]-3-CARBOXAMIDE AS cFMS INHIBITORS | 2010 |
|
RU2562977C2 |
| SERINE/THREONINE KINASE INHIBITORS | 2013 |
|
RU2650501C2 |
| PYRAZOLE PYRIMIDINE DERIVATIVES AND USING THEM AS PDE10 INHIBITORS | 2011 |
|
RU2543386C2 |
| SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TROPOMYOSIN-RELATED KINASE INHIBITORS | 2009 |
|
RU2523544C2 |
