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2 735 661

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IPC

C07C13/271(2006-01-01)

A61K31/45(2006-01-01)

A61K31/47(2006-01-01)

A61P35/00(2006-01-01)

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Application

2019122540, 2019-07-15

(24)

Start date

2019-07-15

(22)

Actual filing date

2019-07-15

(45)

Published

2020-11-05

(72)

Inventor

Dzhemilev Usein MemetovichDyakonov Vladimir AnatolevichKadikova Gulnara NazifovnaDzhemileva Lilya UseinovnaNasretdinov Ramil Nurfaizovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Ufimskij Federalnyj Issledovatelskij Tsentr Rossijskoj Akademii Nauk

METHOD FOR COMBINED PRODUCTION OF 1-HYDROXYMETHYL-SUBSTITUTED BICYCLO[4_2_1]NONA-2,4,7-TRIENES EXHIBITING ANTINEOPLASTIC ACTIVITY Russian patent published in 2020 - IPC C07C13/271 A61K31/45 A61K31/47 A61P35/00

Abstract RU 2735661 C1

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a method for combined production of 1-hydroxymethyl-substituted bicyclo[4.2.1]nona-2,4,7-trienes of general formula (1) and (2), where R=Bu, (CH₂)₃OH, (CH₂)₄OH, which consists in fact that 1,3,5-cycloheptatriene derivative used is 1,3,5-cycloheptatrienyl methanol, as a catalyst Co(acac)₂(dppe)/Zn/ZnI₂, reaction of 1,3,5-cycloheptatrienylmethanol (CGT) with terminal alkynes of general formula (where R is specified above) is carried out at molar ratio alkyne: CGT: Co(acac)₂(dppe) : Zn : ZnI₂ = (1–1.5):1:(0.05–0.15):(0.15–0.45):(0.1–0.3), in ampoule at 20–80 °C, in 2,2,2-trifluoroethanol, for 20–48 hours.

EFFECT: technical result is obtaining novel compounds which can be used in medicine as biologically active substances possessing antitumour activity.

3 cl, 2 tbl, 9 ex

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RU 2 735 661 C1

Authors

Dzhemilev Usein Memetovich

Dyakonov Vladimir Anatolevich

Kadikova Gulnara Nazifovna

Dzhemileva Lilya Useinovna

Nasretdinov Ramil Nurfaizovich

Dates

2020-11-05—Published

2019-07-15—Filed