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2 726 195

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(51)

IPC

C07F7/08(2006-01-01)

C07C2/02(2006-01-01)

A61K31/695(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018144401, 2018-12-14

(24)

Start date

2018-12-14

(22)

Actual filing date

2018-12-14

(45)

Published

2020-07-09

(72)

Inventor

Dzhemilev Usein MemetovichDyakonov Vladimir AnatolevichKadikova Gulnara NazifovnaDzhemileva Lilya UseinovnaNasretdinov Ramil Nurfaizovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Ufimskij Federalnyj Issledovatelskij Tsentr Rossijskoj Akademii Nauk

METHOD OF PRODUCING SI-CONTAINING BICYCLO[4_2_1]NONA-2,4,7-TRIENES EXHIBITING ANTITUMOUR ACTIVITY Russian patent published in 2020 - IPC C07F7/08 C07C2/02 A61K31/695 A61P35/00

Abstract RU 2726195 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic synthesis. Disclosed are Si-containing bicyclo[4.2.1]nona-2,4,7-trienes of formula (1). Disclosed also is a method for synthesis thereof by reacting Si-containing alkynes with 1-methyl (propyl) cycloheptatriene-1,3,5-trien in presence of a catalyst system Ti(acac)₂Cl₂-Et₂AlCl at temperature of 20–80 °C in benzene in for 8–48 hours, use of compounds of formula (1) as agents with antitumour activity.

EFFECT: technical result is obtaining new compounds having antitumour activity.

3 cl, 2 tbl, 2 ex

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RU 2 726 195 C2

Authors

Dzhemilev Usein Memetovich

Dyakonov Vladimir Anatolevich

Kadikova Gulnara Nazifovna

Dzhemileva Lilya Useinovna

Nasretdinov Ramil Nurfaizovich

Dates

2020-07-09—Published

2018-12-14—Filed