FIELD: biotechnology.
SUBSTANCE: disclosed is the use of siRNA for treating and/or preventing an ophthalmic disease or disorder associated with neovascularisation, characterized by high level of expression and/or activity of NRARP gene, wherein said eye disease is selected from a group including age-related macular degeneration (AMD), ischemic retinopathy, diabetic macular edema (DME), proliferative diabetic retinopathy (PDR), diabetic retinal ischemia (DRI), diabetic retinal edema (DRE) and retinopathy of prematurity (ROP) and their combination.
EFFECT: invention discloses siRNAs and their use in methods and compositions for inhibiting NRARP gene expression.
27 cl, 29 dwg, 3 tbl, 2 ex
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