FIELD: medicine; oncology.
SUBSTANCE: invention relates to the field of medicine, namely to oncology; it can be used for the treatment of tumor diseases. In the present invention, a miRNA molecule is proposed, reducing a level of miRNA ubiquitin ligases in a cell, while the specified miRNA molecule contains a sense chain and an antisense chain, where the specified antisense chain contains a complementarity region, wherein at least one nucleotide of a sequence contains a chemical modification selected from 2’-O-methylnucleotide, 3’-internucleotide thiophosphate, and combinations thereof. In addition, pharmaceutical compositions and combinations containing miRNA are proposed.
EFFECT: invention allows for an increase in the efficiency of treatment of oncological diseases.
30 cl, 13 dwg, 4 tbl, 1 ex
| Title |
Year |
Author |
Number |
| MIRNA STRUCTURES WITH HIGH ACTIVITY AND REDUCED EXPOSURE OUTSIDE THE TARGET |
2016 |
- Ying, Wenbin
- Minomi, Kenjirou
- Harborth, Jens
- Cina, Cima
- Zheng, Jane
- Vaish, Narendra
|
RU2788030C2 |
| RNA INTERFERENCE-MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION WITH THE USE OF A SMALL INTERFERING NUCLEIC ACID (siNA) |
2011 |
- Bartz, Stele
- Brown, Duncan
- Robinson, Michael
|
RU2745848C2 |
| DETERMINATION OF NUCLEIC ACIDS BY AMPLIFICATION BASED ON INCORPORATION INTO CHAIN |
2014 |
- Ebojgbodin Kevin
- Brummer Mirko
|
RU2694976C1 |
| METHODS FOR TREATMENT OF HEPATITIS B INFECTION |
2018 |
- Koser, Martin
- Abrams, Marc
|
RU2780021C2 |
| SUBSTANCES FOR TARGETING VARIOUS SELECTED ORGANS OR TISSUES |
2017 |
- De Visser, Peter Christian
- Aartsma-Rus, Adriana Marie
- Jirka, Silvana Maria Gerarda
- Hoen, Peter Abraham Christiaan
- Aguilera Diez, Maria Begona
|
RU2759022C2 |
| DNA AMPLIFICATION METHOD BASED ON CHAIN INSERTION |
2015 |
- Ebojgbodin Kevin
- Brummer Mirko
|
RU2729983C2 |
| NUCLEIC ACID, PHARMACEUTICAL COMPOSITION AND CONJUGATE, METHOD OF PRODUCTION AND USE |
2020 |
- Chzhan, Khunyan
- Gao, Shan
- Kan, Dajvu
|
RU2816898C2 |
| METHODS AND COMPOSITIONS FOR ASSESSMENT OF MEDIATED CRISPR/CAS DESTRUCTION OR CUTOUT AND INDUCED CRISPR/CAS RECOMBINATION WITH EXOGENEOUS DONOR NUCLEIC ACID IN VIVO |
2018 |
- Gun, Gochun
- Khant, Sharlin
- Bridzhes, Syuzanna
- Khartford, Syuzann
- Frendevej, Devid
- Zambrovich, Brajan
- Merfi, Endryu Dzh.
|
RU2782356C2 |
| DELIVERY, USE AND USE IN THERAPY OF CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETED ACTION ON DISORDERS AND DISEASES USING VIRAL COMPONENTS |
2014 |
- Chzhan Fen
- Tsun Le
- Zhan Fej
- Khajdenrajkh Mattias
- Suich Lukash
|
RU2716421C2 |
| COMPOUND FOR MODULATION OF C9ORF72 GENE EXPRESSION AND USE THEREOF |
2013 |
- Bennett Frank C.
- Freier Susan M.
- Swayze Eric E.
- Rigo Frank
|
RU2730677C2 |
