Show metadata Hide metadata

(19)

(11)

2 716 421

(13)

(51)

IPC

C12N15/63(2006-01-01)

C12N9/22(2006-01-01)

C12N15/113(2010-01-01)

C12N5/10(2006-01-01)

A61K48/00(2006-01-01)

(21) (22)

Application

2016101198, 2014-06-11

(24)

Start date

2014-06-11

(22)

Actual filing date

2014-06-11

(45)

Published

2020-03-11

(72)

Inventor

Chzhan FenTsun LeZhan FejKhajdenrajkh MattiasSuich Lukash

(73)

Holder

Te Brod Instityut Ink.Massachusets Instityut Of TeknolodzhiPrezident End Fellouz Of Kharvard Kollidzh

DELIVERY, USE AND USE IN THERAPY OF CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETED ACTION ON DISORDERS AND DISEASES USING VIRAL COMPONENTS Russian patent published in 2020 - IPC C12N15/63 C12N9/22 C12N15/113 C12N5/10 A61K48/00

Abstract RU 2716421 C2

FIELD: biotechnology.

SUBSTANCE: disclosed is a composition containing one or more viral vectors coding CRISPR/Cas system for use in treating a disease or cerebral disorder.

EFFECT: said system due to the presence of at least one nuclear localization signal (NLS) enables efficient editing of the eukaryotic cell genome, in connection with which it can be used to edit genes associated with cerebral diseases in mammals.

20 cl, 85 dwg, 18 tbl, 40 ex

Similar patents RU2716421C2

Title	Year	Author	Number
DELIVERY, CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED ACTION AND MODELING OF DISEASES AND DISORDERS OF POSTMITOTIC CELLS	2014	Chzhan Fen Khajdenrajkh Mattias Suich Lukash	RU2725502C2
DELIVERY, CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND USE IN THERAPY	2013	Chzhan Fen Khajdenrajkh Mattias Zhan Fej Suich Lukash	RU2721275C2
NOVEL ENZYMES AND CRISPR SYSTEMS	2016	Chzhan, Fen Tseche, Bernd Gutenberg, Jonatan, S. Abudaje, Omar, O. Slejmejker, Jan	RU2737537C2
SYSTEM DESIGN, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION	2013	Zhang, Feng Cong, Le Hsu, Patrick Ran, Fei	RU2796017C2
COMPONENTS OF THE CRISPR-CAS SYSTEM, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION	2013	Zhang, Feng Bikard, David, Olivier Cong, Le Cox, David Benjamin, Turitz Hsu, Patrick Jiang, Wenyan Lin, Shuailiang Marraffini, Luciano Platt, Randall, Jeffrey Ran, Fei Sanjana, Neville, Espi	RU2796549C2
COMPOSITIONS AND METHODS OF TREATING HEMOGLOBINOPATHIES	2016	Boitano, Anthony Edward Cooke, Michael Klickstein, Lloyd B. Lescarbeau, Reynald Mickanin, Craig Stephen Mulumba, Kabungo Police, Seshidhar Reddy Snead, Jennifer Stevenson, Susan C. Stewart, Morag Yang, Yi	RU2812491C2
THERAPY METHODS BASED ON CAR T-CELLS WITH INCREASED EFFICIENCY	2016	Motz, Gregory Bushman, Frederic, Dixon Fraietta, Joseph, A. June, Carl, H. Melenhorst, Jan, J. Nobles, Christopher, Loren Young, Regina, M.	RU2788131C2
NEW ENZYMES AND CRISPR SYSTEMS	2016	Kunin Yudzhin Chzhan Fen Volf Yurij I. Shmakov Sergej Severinov Konstantin Semenova Ekaterina Minakhin Leonid Makarova Kira S. Konermann Silvana Dzhung Dzhuliya Gutenberg Dzhonatan S. Abudajekh Omar O.	RU2777988C2
NEW CRISPR ENZYMES AND SYSTEMS	2016	Severinov Konstantin Chzhan Fen Volf Yurij I. Shmakov Sergej Semenova Ekaterina Minakhin Leonid Makarova Kira S. Kunin Yudzhin Konermann Silvana Dzhung Dzhuliya Gutenberg Dzhonatan S. Abudajekh Omar O. Lander Erik S.	RU2771826C2
COMPOSITIONS CONTAINING CURONES AND WAYS OF APPLICATION THEREOF	2018	Kakhvedzhan, Avak Vajnshtejn, Erika Gabriel Pludzhis, Nikolas Makkartni Lebo, Kevin Dzhejms Dias, Fernando Martin Navandar, Dkhanandzhaj Maniklal	RU2822800C2

RU 2 716 421 C2

Authors

Chzhan Fen

Tsun Le

Zhan Fej

Khajdenrajkh Mattias

Suich Lukash

Dates

2020-03-11—Published

2014-06-11—Filed