DOSAGE FORM FOR TREATING AND PREVENTING ULCERATIVE COLITIS, CONTAINING PEGYLATED LIPOSOMAL FORM OF ERYTHROPOIETIN IN FORM OF SUPPOSITORIES, HAVING ANTI-INFLAMMATORY AND IMMUNOMODULATORY EFFECT Russian patent published in 2020 - IPC A61K9/02 A61K31/00 A61K38/18 A61K47/10 A61P1/04 

FIELD: medicine.

SUBSTANCE: present invention refers to medicine, namely to a method for preparing a medicinal agent for treating and preventing ulcerative colitis in the form of suppositories containing PEGylated liposomal form of erythropoietin (EPO), characterized in that the suppository base is prepared by melting polyoxyethylene glycol 4000, the emulsifying agent T-2, Kolliphor and Cremophor RH 40 at a temperature of not more than 70 °C, adding polyoxyethylene glycol 1500 and polyoxyethylene glycol 400 and stirring obtained base, introducing a liposomal emulsion containing EPO and a lipid film from a mixture of lecithin and polyoxyethylene glycol 2000, and suppositories are prepared from the suppository mass by pouring, comprising: Erythropoietin - 2000 ME, Polyoxyethylene glycol 4000 - 0.75 g, Polyoxyethylene glycol 1500 - 0.5 g, Polyoxyethylene glycol 400 - 0.5 g, Polyoxyethylene glycol 2000 - 0.25 g, Lecithin - 0.05 g, Emulsifier T2 - 0.1 g, Cremophor RH 40 - 1.25 g, Kolliphor - 0.75 g.

EFFECT: present invention provides a new domestic drug preparation for treating ulcerative colitis, which is a PEGylated liposomal form of EPO and containing PEG 4000, PEG 1500, PEG 400, T2, Cremophor RH as auxiliary substances, a Kolliphor for preparing a dosage form in the form of rectal suppositories for local treatment of ulcers of the large and small intestine, characterized by ease of use, as well as the presence of anti-inflammatory and immunomodulatory effect.

1 cl, 5 dwg, 5 ex