RADIOPHARMACEUTICAL SOLUTIONS WITH PREFERRED PROPERTIES Russian patent published in 2021 - IPC A61K51/04 A61K51/10 A61P35/04 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a radiopharmaceutical solution containing free ²²⁴Ra and a complexing agent capable of forming complex with ²¹²Pb. Disclosed is a radiopharmaceutical solution containing a complexing agent complex and ²¹²Pb, which is not part of complex ²²⁴Ra, wherein said complexing agent is selected from a group consisting of DOTMP, EDTMP, bisphosphonate, pamidronate conjugated with DOTA, pamidronate conjugated with TCMC, TCMC, DOTA, p-SCN-Bn-DOTA, p-SCN-Bn-TCMC, conjugated with DOTA antibody and conjugated with TCMC antibody. Invention also discloses kits using the disclosed radiopharmaceutical solution for treating metastases in a bone system and a method of providing said solution.

EFFECT: use of directed chelate absorbers of daughter nuclide ²²⁴Ra opens possibility of using ²²⁴Ra-based solutions for medical treatment.

25 cl, 8 dwg, 14 ex