COMPLEX CONTAINING A PSMA-TARGETING COMPOUND BOUND TO A LEAD OR THORIUM RADIONUCLIDE Russian patent published in 2023 - IPC C07D257/02 C07B59/00 A61K51/04 A61P35/00 A61P35/04 A61K103/00 A61K103/40

Abstract RU 2795398 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound comprising a PSMA-targeted unit and a chelating unit, wherein the PSMA-targeted unit is bonded via a carbon backbone to the chelating unit, and wherein the compound is characterized by the following formula

where X represents either -NH₂ or -OH. Also a complex for use in radioligand therapy is proposed that contains the above compound complexed with a radionuclide selected from the group consisting of ²¹²Pb, ²¹²Bi, ²¹³Bi, ²²⁵Ac or ²²⁷Th, a pharmaceutical composition containing the complex, the use of a pharmaceutical composition, a method for treating a disease characterized by PSMA expression, and kits.

EFFECT: invention makes it possible to obtain complex compounds with high radiobiological efficiency to treat a disease characterized by PSMA expression.

18 cl, 2 dwg, 7 tbl, 17 ex

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RU 2 795 398 C2

Authors

Larsen, Roy Hartvig

Dates

2023-05-03—Published

2018-12-13—Filed