HESPERIDINE CONJUGATE AND METHOD FOR PREPARATION THEREOF Russian patent published in 2021 - IPC C07H17/06 A61K31/353 C07B43/00 

Abstract RU 2742030 C1

FIELD: medicine.

SUBSTANCE: invention relates to biomedicine (1-[(E)-[5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2R,3S,4R,5R,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chroman-4-ylidene]amino]guanidine, having structural formula:

as well as a method for production thereof. Method is realized by reaction of narperidin with aminoguanidine hydrochloride in an organic solvent in the presence of hydrochloric acid.

EFFECT: disclosed is a novel compound having good solubility in aqueous media combined with stability in a wide range of pH values and ability to trap various types of damaging agents, such as reactive oxygen species, reducing sugars, glyoxal and methylglyoxal.

3 cl, 6 tbl, 4 ex

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RU 2 742 030 C1

Authors

Burov Sergej Vladimirovich

Smirnov Vyacheslav Sergeevich

Leko Mariya Viktorovna

Kudryavtseva Tatyana Anatolevna

Dates

2021-02-01Published

2020-06-11Filed