FIELD: medicine; chemistry.
SUBSTANCE: invention relates to formula compounds used in medicine IA IA, where Z represents
, wherein the rings AZ are a saturated, unsaturated or aromatic ring optionally containing O, N or S atoms; L-L16 are aliphatic groups optionally substituted with -C(O)-, -O-, NH or N (C1-6 aliphatic group); JA-JZ is a halogen, -CN, -NO2, XJ, QJ or XJ-QJ; or two groups from JA-JZ optionally form -C=N-OH, -C(O)- or a saturated ring containing O, N or S atoms; optionally substituted with halogen, oxo, XJ, QJ or XJ-QJ; XJ is C1-10 an aliphatic group optionally substituted with -O-, -NH, N(C1-6 aliphatic group), -C(O)-, -S(O)2-; QJ is a saturated, unsaturated or aromatic ring optionally containing O, N or S atoms; XJ is optionally substituted with halogen, OH or CN; QJ is optionally substituted with halogen, oxo, CN or C1-6 alkyl optionally substituted with -O- or -C(O)-.
EFFECT: novel compounds, effective methods for their preparation, a pharmaceutical composition based on them, effective for treating or preventing a bacterial infection of the urinary tract and inflammatory bowel disease.
106 cl, 216 ex, 2 tbl, 5 dwg
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Authors
Dates
2018-09-14—Published
2013-12-18—Filed