PHARMACEUTICAL COMPOSITION CONTAINING ONE OR MORE ESTERS OF FUMARIC ACID IN A DECOMPOSABLE MATRIX Russian patent published in 2021 - IPC A61K9/28 A61K9/22 A61K31/194 A61K31/231 A61K47/38 A61K47/26 A61P17/00 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to pharmaceutical compositions of fumaric acid esters. Pharmaceutical composition in form of a tablet with a degradable matrix contains core containing 35–55 % by weight of a dimethyl fumarate nucleus; 3–6 wt % hydroxypropyl cellulose core; 40–60 % by weight of lactose nucleus; 0.15–0.7 % by weight of magnesium stearate nucleus and 0.05–0.25 % by weight of silicon dioxide core; and an enteric coating which is applied at 1.5–3.5 % by weight of the core. Also disclosed is a method of treating and using a pharmaceutical composition for treating psoriasis, psoriatic arthritis, neurodermatitis, inflammatory bowel disease, Crohn's disease, nonspecific ulcerative colitis, polyarthritis, multiple sclerosis, juvenile sugar diabetes, Hashimoto thyroiditis, Graves' disease, systemic lupus erythematosus, Sjogren's syndrome, pernicious anemia, chronic active (lupous) hepatitis, rheumatoid arthritis, lupus nephritis, pemphigus, scleroderma, organ transplant rejection, myasthenia gravis, uveitis, refractory uveitis, spring conjunctivitis or optic neuritis and other diseases.

EFFECT: group of inventions provides controlled release of fumaric acid esters.

19 cl, 2 dwg, 2 tbl, 43 ex