FIELD: chemistry.
SUBSTANCE: invention relates to a method for producing isothiobarbamine from 5-isopropyl-2-thiobarbituric acid and N, N-diethyl-2-chloroethane-1-amine hydrochloride by heating the reaction mass in a solvent medium, using a previously prepared solution of N, N-diethyl -2-chloroethane-1-amine, and the reaction is carried out in anhydrous isopropanol at boiling for 29 hours with protection from moisture and carbon dioxide.
EFFECT: disclosed is a new method of producing isothiobarbamine of high purity and in high yield, which can be used for the synthesis of isothiobarbituric acid.
1 cl
| Title | Year | Author | Number |
|---|---|---|---|
| HYDROCHLORIDE 2(***-DIETHYLAMING)ETHYL-5-ISOPROPULTHIOBARBITURIC ACID PROCESSING ANHYPOXIA AND ACTOPROTECTING ACTION | 0 |
|
SU552789A1 |
| METHOD OF PREPARING HEMCITABIN HYDROCHLORIDE | 1995 |
|
RU2154648C2 |
| METHOD OF OBTAINING DERIVATIVES OF 6-AMINO-5B, 19-CYCLOANDROSTANE OR SALTS THEREOF | 0 |
|
SU680652A3 |
| DERIVATIVES OF OXADIAZOALYLALKYLPURINE DISPLAYING ANTI-COUGH ACTIVITY | 0 |
|
SU1602862A1 |
| DERIVATIVES OF 5-(AMINO-SUBSTITUTED)-1,2,4-TRIAZOLO-[1,5-A]-PYRIMIDINE, THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS, PHARMACEUTICAL COMPOSITION SHOWING CARDIOTONIC AND CORONARY-DILATING ACTION AND A METHOD OF CARDIOTONIC AND/OR CORONARY-DILATING EFFECT ON HEART | 1992 |
|
RU2097382C1 |
| PROCESS FOR PREPARING 1,2,3,9-TETRAHYDRO -9-METHYL -3-[(2-METHYL-1H-IMIDAZOL -1-YL)METHYL]-4H- CARBAZOL-4-ONE OR SALTS THEREOF OR HYDRATES THEREOF, AND INTERMEDIATE PRODUCTS OF SYNTHESIS THEREOF | 1993 |
|
RU2041876C1 |
| DERIVATIVES OF BENZOFURAN, BENZOTHIOPHENE, INDOLE OR INDOLYSINE, METHODS OF THEIR SYNTHESIS, COMPOSITION SHOWING ANTIARRHYTHMIC EFFECT | 1991 |
|
RU2095357C1 |
| NOVEL PYRAZOLE PYRIMIDINE DERIVATIVES | 2017 |
|
RU2769448C2 |
| COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND INHIBITORS OF GARET, METHOD OF INHIBITION AND PROLIFERATION AND DERIVATIVES OF THIOPHENE CARBOXYLIC ACID ESTER | 1995 |
|
RU2152945C2 |
| 0 |
|
SU166614A1 |
