COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND INHIBITORS OF GARET, METHOD OF INHIBITION AND PROLIFERATION AND DERIVATIVES OF THIOPHENE CARBOXYLIC ACID ESTER Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel compounds of the general formula (I) where A means CH₂ or S; Z means C₁-C₃-alkylene; X means C₁-C₆-alkyl and R₁ and R₂ mean hydrogen atom. Compounds of the formula (I) existing in equilibrium with their 4-hydroxy-tautomers and in forms of diastereomeric mixtures and their pharmaceutically acceptable salts are strong inhibitors of GARET. These compounds and their salts are useful antiproliferative agents also. Invention describes also method of inhibition and proliferation and derivatives of thiophene carboxylic acid ester. EFFECT: improved method of inhibition and proliferation, valuable pharmacological properties. 14 cl, 3 tbl, 2 ex