Patenton — panteon of patents

(19)

RU

(11)

2 746 754

(13)

C2

(51)

IPC

A61K39/395(2006-01-01)

A61P35/00(2006-01-01)

C07K16/46(2006-01-01)

C07K16/28(2006-01-01)

(21) (22)

Application

2018135317, 2017-02-24

(24)

Start date

2017-02-24

(22)

Actual filing date

2017-02-24

(45)

Published

2021-04-20

(72)

Inventor

Kinosita YasukoKavaj YumikoTsunenari TosiakiIsiguro TakakhiroEndo MikaSano Yudzi

(73)

Holder

Chugai Seiyaku Kabushiki Kaisha

CELL DAMAGE INDUCING THERAPEUTIC MEDICINAL PRODUCT FOR ANTICANCER THERAPY Russian patent published in 2021 - IPC A61K39/395 A61P35/00 C07K16/46 C07K16/28 

Abstract RU 2746754 C2

FIELD: biotechnology.

SUBSTANCE: proposed is an anti-cancer agent containing a bispecific antibody as an active ingredient. Stated bispecific antibody contains variable areas of the antibody connecting with glypican 3 and CD3 and contains identical light strands. Also proposed is a pharmaceutical composition containing a bispecific antibody as an active ingredient. Composition is intended for co-use with another anti-cancer medicinal product. Invention also relates to cytotoxicity induction, cellular proliferation inhibition and immune response activation agents containing such composition. Bispecific antibodies constitute new and highly safe molecules characterized by high processability, strong antitumor activity and very high pharmacokinetic properties.

EFFECT: invention may be used in treatment of various types of cancer.

17 cl, 47 dwg, 21 tbl, 15 ex

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RU 2 746 754 C2

Authors

Kinosita Yasuko

Kavaj Yumiko

Tsunenari Tosiaki

Isiguro Takakhiro

Endo Mika

Sano Yudzi

Dates

2021-04-20—Published

2017-02-24—Filed

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