CANCER TREATMENT WITH CHIMERIC CD33 ANTIGEN RECEPTOR Russian patent published in 2021 - IPC C07K16/28 C07K16/30 C07K14/705 C07K14/715 A61K39/395 A61P35/00 A61P35/02 A61P37/04 

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular to a nucleic acid molecule encoding a chimeric antigen receptor (CAR) for binding to CD33, binding CD33 domain, as well as a chimeric antigen receptor (CAR) polypeptide for binding to CD33. Also disclosed is a vector, an immune effector cell and a population of immune effector cells containing the above molecule, as well as a method for obtaining the above cell and population. The invention also relates to a method of providing immunity against a CD33-expressing tumor in a mammal, to a method of conditioning a subject having a CD33-expressing cell prior to cell transplantation, comprising the use of the above substances.

EFFECT: invention makes it possible to effectively treat a mammal with a disease associated with CD33 expression.

59 cl, 58 dwg, 13 tbl, 10 ex