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(19)

RU

(11)

2 745 451

(13)

C1

(51)

IPC

C07K16/24(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

C12N5/10(2006-01-01)

C12P21/08(2006-01-01)

A61K39/395(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2019137963, 2018-05-25

(24)

Start date

2018-05-25

(22)

Actual filing date

2018-05-25

(45)

Published

2021-03-25

(72)

Inventor

Surh, Charles D.Lee, Jun-Young

(73)

Holder

Institute For Basic SciencePostech Academy-Industry Foundation

ANTIBODIES TO HUMAN INTERLEUKIN-2 AND THEIR APPLICATION Russian patent published in 2021 - IPC C07K16/24 C12N15/13 C12N15/63 C12N5/10 C12P21/08 A61K39/395 A61P35/00 

Abstract RU 2745451 C1

FIELD: immunology.

SUBSTANCE: present invention relates to the field of immunology. An anti-hIL-2 antibody or an antigen-binding fragment thereof, a nucleic acid, a recombinant vector and a method for producing an anti-hIL-2 antibody or an antigen-binding fragment thereof are disclosed. Also disclosed are a complex for use in minimizing Treg cell expansion and stimulation of CD8+ T cells and NK cells and a composition for use in the prevention or treatment of cancer. In addition, a composition for coadministration for use in treating cancer and a composition for use in enhancing vaccine efficacy are described.

EFFECT: invention can be used as an anti-cancer therapy.

15 cl, 10 dwg, 8 tbl, 7 ex

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RU 2 745 451 C1

Authors

Surh, Charles D.

Lee, Jun-Young

Dates

2021-03-25—Published

2018-05-25—Filed

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