FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to an isolated antibody that specifically binds human CD73 on the cell surface and is able to neutralize its 5' - ectonucleotidase activity. A pharmaceutical composition for cancer treatment containing the above antibody is also disclosed. The invention also relates to a recombinant host cell producing the above antibody.
EFFECT: invention makes it possible to effectively treat cancer.
20 cl, 2 tbl, 9 ex, 8 dwg
Title | Year | Author | Number |
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CD73 BLOCKING ANTIBODIES | 2020 |
|
RU2819204C2 |
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RU2811477C2 |
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RU2831409C2 |
CD3-BINDING DOMAIN | 2015 |
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RU2742691C2 |
CHIMERIC ANTIGEN RECEPTOR | 2018 |
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RU2770002C2 |
MULTISPECIFIC ANTIBODIES AND METHODS FOR PRODUCTION AND USE THEREOF | 2018 |
|
RU2837770C2 |
Authors
Dates
2021-04-21—Published
2015-10-09—Filed