FIELD: biotechnology.
SUBSTANCE: invention relates to a tetraspecific antibody monomer that binds to CD19, CD3, 4-1BB and PD-L1, as well as to an antibody containing it. Also an isolated nucleic acid encoding the above antibody is disclosed, as well as a vector and a cell containing it are disclosed. The invention also relates to a method of producing a tetraspecific antibody, including culturing the above host cell, as well as a composition containing the above antibody.
EFFECT: invention is effective for the treatment of cancer associated with CD19, CD3, 4-1BB and PD-L1.
21 cl, 8 dwg, 2 ex
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