HYDROCORTISONE DERIVATIVE FOR ALZHEIMER'S DISEASE TREATMENT Russian patent published in 2021 - IPC A61K31/573 A61P25/28 

Abstract RU 2748437 C2

FIELD: medicine.

SUBSTANCE: invention relates to the use of 21-hemisuccinate hydrocortisone (RX624) as Alzheimer's disease treatment, as well as to the use of 21-hemisuccinate hydrocortisone in the production of drugs for the treatment of Alzheimer's disease.

EFFECT: use of RX624 in transgenic mice with genetically determined Alzheimer's disease leads to selective inhibition of the formation of the exogenous GAFD-A complex and stops memory impairment in animals according to the results in the Morris water test.

2 cl, 3 ex, 4 dwg

Similar patents RU2748437C2

Title Year Author Number
4-(3-((2-ADAMANTYL)AMINO)-3-OXOPROP-1-EN-1-YL)-N-HYDROXYBENZAMIDE - A NEW DRUG FOR THE TREATMENT OF ALZHEIMER'S DISEASE 2022
  • Neganova Margarita Evgenevna
  • Aleksandrova Yuliya Romanovna
  • Munkuev Aldar Ayurovich
  • Suslov Evgenij Vladimirovich
  • Volcho Konstantin Petrovich
  • Salakhutdinov Nariman Faridovich
RU2783995C1
REDUCED SYSTEMIC LEVEL OF REGULATORY T-CELLS OR THEIR ACTIVITY FOR TREATING CNS DISEASES AND TRAUMAS 2016
  • Eisenbach-Schwartz, Michal
  • Baruch, Kuti
RU2741366C2
REDUCED SYSTEMIC LEVELS OR ACTIVITY OF REGULATORY T-CELLS FOR TREATING DISEASE AND CENTRAL NERVOUS SYSTEM INVOLVEMENT 2017
  • Eisenbach-Schwartz Michal
  • Baruch Kuti
  • Rosenzweig Neta
RU2815892C1
REDUCED LEVELS OR ACTIVITY OF SYSTEMIC REGULATORY T CELLS FOR TREATING DISEASE OR CNS INJURY 2015
  • Eisenbach-Schwartz Michal
  • Baruch Kuti
  • Rosenzweig Neta
RU2690670C2
PEPTIDE AND METHOD OF TREATMENT OF ALZHEIMER'S DISEASE 2018
  • Morozov Aleksandr Olegovich
RU2679080C1
METHOD FOR TREATING NEURODEGENERATIVE DISEASES 2021
  • Patrakhanov Evgenij Aleksandrovich
  • Pokrovskij Mikhail Vladimirovich
  • Korokin Mikhail Viktorovich
  • Chuev Vladimir Petrovich
  • Buzov Andrej Anatolevich
  • Kazakova Valentina Sergeevna
RU2777871C1
PEPTIDE AND METHOD OF TREATMENT OF ALZHEIMER'S DISEASE 2018
  • Morozov Aleksandr Olegovich
RU2679059C1
USE OF A BENZOPYRAN DERIVATIVE FOR THE TREATMENT OF DEMENTIA OF ALZHEIMER'S TYPE ASSOCIATED WITH CALCIUM DYSREGULATION 2023
  • Zernov Nikita
  • Melenteva Daria Maksimovna
  • Bolshakova Anastasiia Viktorovna
  • Popugaeva Elena Aleksandrovna
RU2804398C1
TARGETED NON-INVASIVE TRANSPLANTATION INTO BRAIN OF FUNCTIONALLY ACTIVE MITOCHONDRIA FOR TREATING NEURODEGENERATIVE DISEASES 2019
  • Bobkova Natalya Viktorovna
  • Zhdanova Darya Yurevna
  • Belosludtseva Natalya Valerevna
  • Mironova Galina Dmitrievna
RU2744453C2
PHARMACEUTICAL COMPOSITION BASED ON HAEE PEPTIDE FOR TREATING NEURODEGENERATIVE DISEASES 2019
  • Kozin Sergej Aleksandrovich
  • Morozov Aleksandr Olegovich
  • Chuev Vladimir Petrovich
  • Buzov Andrej Anatolevich
  • Kazakova Valentina Sergeevna
RU2709539C1

RU 2 748 437 C2

Authors

Guzhova Irina Vladimirovna

Kozin Sergej Aleksandrovich

Lazarev Vladimir Fedorovich

Makarov Aleksandr Aleksandrovich

Margulis Boris Aleksandrovich

Mitkevich Vladimir Aleksandrovich

Mikhajlova Elena Radislavovna

Suezov Roman Vladimirovich

Dates

2021-05-25Published

2019-10-28Filed