PROTEINKINASE INHIBITORS, METHOD FOR OBTAINING THEREOF AND MEDICAL APPLICATION Russian patent published in 2021 - IPC C07D401/14 C07D471/04 A61K31/506 A61P35/00 

FIELD: biochemistry.

SUBSTANCE: invention relates to compounds of Formula I, their deuterated derivatives and pharmaceutically acceptable salts, while in the Formula R₁ represents a hydrogen atom or C₁-C₆ alkyl; R₂ and R₃ represent C₁-C₆ alkyl or R₂ and R₃ together with C atom to which they are attached form C₃-C₆ cycloalkyl; R₄ and R₅ are independently selected from hydrogen and halogen, and at least one of R₄ and R₅ represent halogen; R₆ selected from a hydrogen atom or C₁-C₆ alkyl; R₇ represents , Z is O or , and n is an integer from 0 to 4; each of W and Y is independently C or N, but both W and Y cannot be C at the same time, and if Z is O, W is C; R₁₀, R₁₁, R₁₂ and R₁₃ are independently selected from a hydrogen atom, C₁-C₆ alkyl, C₁-C₆ hydroxyalkyl or cyclopropylmethyl, or R₆ and R₇ together with the C atoms to which they are attached form a 6-membered heterocycle containing one N atom, which is substituted by ; R₈ represents C₁-C₆ hydroxyalkyl. The invention also relates to intermediates of Formula VI, a method for the preparation and use of compounds of Formula I, a pharmaceutical composition, a kit and methods of treatment.

EFFECT: compounds of Formula I are obtained with inhibitory activity against CDK 4/6.

29 cl, 12 tbl, 52 ex