FIELD: chemistry.
SUBSTANCE: present invention relates to novel compounds of formulae 1 and 2 which have anti-tumour activity. Compounds correspond to formula 1 and 2 
(1), 
(2). Invention also relates to a pharmaceutical composition comprising, in an effective amount, compound 1 or 2, a pharmaceutically acceptable carrier and optionally an additional therapeutic agent comprising paclitaxel.
EFFECT: compounds can be used to treat various disorders, diseases and pathological conditions mediated by the activity of protein kinases involved in the pathogenesis of a wide variety of cancers, for example pancreatic carcinoma.
4 cl, 59 dwg, 2 tbl, 135 ex
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