FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology. Nucleic acid molecules encoding chimeric antigen receptors (CAR) and expression vectors containing them are proposed. CARs include an extracellular domain that includes IL-13 or its variant that binds to interleukin-13Rα2 (IL13Rα2), a transmembrane region, a costimulating domain, and an intracellular signaling domain. A population of human T- cells expressing CAR targeted IL13Rα2. The human T- cell population contains central memory T- cells. In addition, the invention relates to a composition for the treatment of cancer containing the specified population of T- cells.
EFFECT: invention provides improved antitumor efficacy due to improved resistance of T- cells in the tumor micro environment.
10 cl, 27 dwg, 5 tbl, 12 ex
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| CELL | 2014 |
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