FIELD: pharmaceutics.
SUBSTANCE: group of inventions relates to the field of pharmaceutics, it can be used for the treatment of brain cancer. A nucleic acid molecule encoding a chimeric antigen receptor is disclosed, wherein the given chimeric antigen receptor contains amino acid sequence SEQ ID NO: 26 or SEQ ID NO: 27. A human T-cell population, a composition for using in the treatment of brain cancer, expressing HER2, in patient, and a chimeric antigen receptor are also disclosed.
EFFECT: group of inventions provides for improved antitumor specificity.
11 cl, 18 dwg, 3 tbl, 9 ex
| Title |
Year |
Author |
Number |
| INTRODUCTION OF CONSTRUCTED T CELLS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM CANCER |
2017 |
- Badi Benkhem
- Braun Kristin E.
- Formen Stiven Dzh.
- Prajsmen Sol Dzh.
|
RU2757308C2 |
| CHIMERIC ANTIGEN RECEPTORS AIMED AT PSCA |
2016 |
- Prajsmen, Sol Dzh.
- Braun, Kristin E.
- Formen, Stiven Dzh.
|
RU2759879C2 |
| T- CELLS WITH COSTIMULATING CHIMERIC ANTIGEN RECEPTOR TARGETING IL13Rα2 |
2015 |
- Braun Kristin E.
- Formen Stiven Dzh.
|
RU2749922C2 |
| CENTRAL MEMORY T-CELLS FOR ADOPTIVE T-CELL THERAPY |
2015 |
- Braun Kristin E.
- Formen Stiven Dzh.
|
RU2763523C2 |
| T-CELLS MODIFIED WITH CHIMERIC ANTIGEN RECEPTOR TARGETED TO CS1 FOR TREATMENT OF AMYLOIDOSIS AL |
2018 |
- Van, Syuli
- Formen, Stiven Dzh.
|
RU2774895C2 |
| T-CELLS MODIFIED WITH A CHIMERIC ANTIGEN RECEPTOR TARGETING CS1 |
2015 |
- Formen Stiven Dzh.
- Van Syuli
|
RU2727451C2 |
| MODIFIED NON-NATURAL NKG2D LIGANDS WHICH SELECTIVELY DELIVER ATTACHED HETEROLOGOUS MOLECULES TO NON-NATURAL NKG2D RECEPTORS ON CAR CELLS |
2020 |
- Kim, Kaman
- Kileen, Nigel
- Herzig, Eytan
- Greene, Warner
|
RU2823728C2 |
| METHODS FOR PRODUCING CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTOR |
2015 |
- Bedoya Felipe
- Ghassemi Saba
- June Carl H.
- Levine Bruce L.
- Melenhorst Jan J.
- Milone Michael C.
- Powell Daniel J. Jr.
- Zheng Zoe
|
RU2751362C2 |
| CHIMERIC ANTIGEN RECEPTORS TARGETED TO FC RECEPTOR-LIKE PROTEIN 5, AND THEIR USE |
2015 |
- Brentjens Renier J.
- Smith Eric L.
- Liu Cheng
|
RU2779747C2 |
| HETERODIMERIC FUSED PROTEINS IL-15/IL-15Pα-Fc AND USE THEREOF |
2019 |
- Bernett, Matthew
- Desjarlais, John
- Rashid, Rumana
- Varma, Rajat
- Bonzon, Christine
|
RU2827796C2 |
