AQUEOUS PHARMACEUTICAL COMPOSITION OF ANTI-IL17A ANTIBODY AND ITS APPLICATION Russian patent published in 2021 - IPC A61K39/395 A61K47/18 A61K47/26 A61K47/12 A61P43/00 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to aqueous compositions for anti-IL17a antibodies. An aqueous pharmaceutical composition suitable for parenteral administration to a subject to inhibit the activity of an IL17a protein contains pharmaceutically effective amount of an anti-IL17a antibody containing a VHH-derivative domain and a variable V_L domain; a histidine-based buffer agent; and effective amount of sugar-based alcohol as an osmotic agent. Another option of an aqueous pharmaceutical composition, the use of an aqueous pharmaceutical composition for the treatment of an IL17a-mediated disease, a method for the treatment of an IL17a-mediated disease, a method for obtaining an aqueous pharmaceutical composition are also disclosed.

EFFECT: group of inventions provides colloidal stability, thermal stability, reduction of antibody aggregation and homogeneity of antibodies in the composition.

37 cl, 33 dwg, 44 tbl, 10 ex