FIELD: medicine; pharmaceutics.
SUBSTANCE: group of inventions relates to pharmaceutics and medicine. Object 1 is a combination for treating a tumour in the biliary system, liver cancer, triple negative breast cancer or lung cancer, containing an anti-PD-L1 antibody and anlotinib. Objects 2 and 3 are a method of treating a tumour in the biliary system, liver cancer, thrice-negative breast cancer and/or lung cancer, involving administering to a subject an anti-PD-L1 antibody and anlotinib, including in the form of the above combination. Object 4 is a kit for treating a tumour in the biliary system, liver cancer, triple negative breast cancer and/or lung cancer, containing a pharmaceutical composition based on an anti-PD-L1 antibody, a pharmaceutical composition based on anlotinib.
EFFECT: synergistic antitumour effect of the combination of the anti-PD-L1 antibody and anlotinib on the tumour in the biliary system, in liver cancer, in triple-negative breast cancer, in lung cancer compared to any drug of the combination administered separately.
16 cl, 4 tbl, 4 ex
| Title |
Year |
Author |
Number |
| ANTIBODY TO PD-L1, ITS ANTIGEN-BINDING FRAGMENT, AND THEIR PHARMACEUTICAL USE |
2019 |
- Gu, Xiaoling
- Jiang, Jiahua
- Zhang, Lei
- Hu, Qiyue
- Gu, Jinming
- Tao, Weikang
|
RU2778085C2 |
| PHARMACEUTICAL COMPOSITION OF THE FUSION PROTEIN OF THE TRANSFORMING GROWTH FACTOR BETA RECEPTOR AND ITS APPLICATION |
2019 |
- Tyan, Chenmin
- Li, Khao
- Lyu, Syun
|
RU2791683C2 |
| PHARMACEUTICAL COMPOSITION BASED ON ANTIBODY TO PD-L1 AND ITS APPLICATION |
2018 |
- Yan, Zhen
- Yang, Jianjian
- Yan, Xiaodan
- Wu, Shan
- Liu, Xun
|
RU2766590C2 |
| ANTIBODY TO B7-H4, ITS ANTIGEN-BINDING FRAGMENT AND ITS PHARMACEUTICAL USE |
2019 |
- Bao Rudi
- Hua Haiqing
- Liu Suxia
- Zhang Fujun
- Wang Ting
|
RU2792748C2 |
| ANTI-BCMA ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF AND MEDICAL USE THEREOF |
2020 |
|
RU2819660C2 |
| ANTIBODY TO B7H3-EXATECAN ANALOGUE CONJUGATE AND ITS USE IN MEDICINE |
2019 |
- In, Khua
- Chzhan, Lin
- Chzhan, Tin
- Chzhan, Lej
- Syuj, Tszyanyan
- Tao, Vejkan
|
RU2785664C2 |
| ANTI-PD-L1/ANTI-4-1BB BISPECIFIC ANTIBODY IN HETERODIMERIC FORM, SIMILAR IN STRUCTURE TO NATURAL ANTIBODY, AND PRODUCTION THEREOF |
2022 |
- Liu Jiawang
- Yang Yaping
- Zhao Siqi
- Liu Yang
- Song Nanmeng
- Fan Fei
- Su Kaixuan
- Zhang Lanxin
- Wang Jing
- Xu Jiangcheng
- Lee Kyoung Woo
|
RU2825838C1 |
| FUSED PROTEIN CONTAINING TGF-BETA RECEPTOR, AND ITS PHARMACEUTICAL USE |
2018 |
- Gu, Tszinmin
- Lo, Syao
- Tao, Vejkan
|
RU2776204C1 |
| ANTIBODY TO PD-1, ITS ANTIGEN-BINDING FRAGMENT AND ITS PHARMACEUTICAL USE |
2020 |
- Gu Xiaoling
- Ye Xin
- Ge Hu
- Tao Weikang
|
RU2807484C2 |
| USE OF COMBINATION OF ANTIBODY TO PD-1 AND VEGFR INHIBITOR IN PRODUCTION OF DRUG FOR TREATMENT OF MALIGNANT NEOPLASMS |
2017 |
- Sun, Sin
- Tsao, Gotsin
- Yan, Chanyun
- Chzhan, Lyanshan
- Go, Yun
|
RU2762746C2 |
