FIELD: medicine.
SUBSTANCE: invention relates to variants of a trispecific binding molecule comprising a variable VHH domain, specifically binding human IL-17A and IL-17F, and a domain containing variable heavy and light chain domains and specifically binding human TNF-alpha. Also proposed: nucleic acid encoding said molecule, expression vector, host cell and method for producing a trispecific molecule according to the invention. In addition, a pharmaceutical composition and methods for treating diseases mediated by human IL-17A, IL-17F or TNF-alpha, such as rheumatoid arthritis, psoriasis or psoriatic arthritis, are presented.
EFFECT: this invention may find further application in the prevention and treatment of various autoimmune and inflammatory disorders.
27 cl, 29 dwg, 11 tbl, 30 ex
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