FIELD: biochemistry.
SUBSTANCE: invention relates to the field of biochemistry, in particular to an antibody or its antigen-binding fragment, which specifically bind to ligand 1 of human programmed cell death receptor (hereinafter – PD-L1). An expression vector containing a nucleic acid molecule, which encodes the antibody or its antigen-binding fragment; a composition, a kit, a hybrid protein containing the specified antibody are also disclosed. A method for the treatment using the specified antibody and the use of the specified antibody when producing a drug for the treatment or prevention of hPD-L1-mediated disease are disclosed.
EFFECT: invention has the capability of effective treatment of diseases related to ligand 1 of human programmed cell death receptor (PD-L1).
46 cl, 37 dwg, 22 tbl, 32 ex
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