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(19)

(11)

2 757 815

(13)

(51)

IPC

C07K16/32(2006-01-01)

C07K19/00(2006-01-01)

A61K47/68(2017-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018119686, 2016-11-22

(24)

Start date

2016-11-22

(22)

Actual filing date

2016-11-22

(45)

Published

2021-10-21

(72)

Inventor

Ma, DangsheMarquette, Kimberly AnnGraziani, Edmund IdrisSapra, PujaTumey, Lawrence NathanPrashad, Nadira AnarkaliKhandke, Kiran ManoharBennett, Eric M.Tchistiakova, Lioudmila

(73)

Holder

Pfizer Inc.

ANTIBODIES AND ANTIBODY FRAGMENTS FOR SITE-SPECIFIC CONJUGATION Russian patent published in 2021 - IPC C07K16/32 C07K19/00 A61K47/68 A61P35/00

Abstract RU 2757815 C2

FIELD: biotechnology.

SUBSTANCE: antibody binding HER2 is proposed, including injected Cys residues for site-specific conjugation. Antibody-drug conjugate (hereinafter – ADC) containing the specified antibody conjugated with a therapeutic agent and a pharmaceutical composition for the treatment of cancer including ADC are also proposed.

EFFECT: invention provides for obtaining ADC with improved pharmacokinetic profile.

11 cl, 42 dwg, 50 tbl, 25 ex

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RU 2 757 815 C2

Authors

Ma, Dangshe

Marquette, Kimberly Ann

Graziani, Edmund Idris

Sapra, Puja

Tumey, Lawrence Nathan

Prashad, Nadira Anarkali

Khandke, Kiran Manohar

Bennett, Eric M.

Tchistiakova, Lioudmila

Dates

2021-10-21—Published

2016-11-22—Filed