FIELD: biotechnology.
SUBSTANCE: group of inventions relates to biotechnology and can be used in medicine. Invention discloses an anti-claudin antibody conjugate with at least one exatecan fragment (see compound of general formula (Pc-L-Y-D)), where Pc is an antibody to claudin 18.2 or its antigen-binding fragment, and L, Y and n are as defined in the present description.
EFFECT: invention can be used in preparing a drug for treating cancer, the cells of which are characterized by high expression of claudin 18.2.
31 cl, 16 ex, 17 tbl, 5 dwg
| Title |
Year |
Author |
Number |
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|
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|
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|
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|
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|
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|
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| ERIBULIN DERIVATIVE DRUG CONJUGATE, METHOD FOR PREPARATION THEREOF AND USE THEREOF IN MEDICINE |
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|
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|
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| ANTIBODY TO PD-1, ITS ANTIGEN-BINDING FRAGMENT AND ITS PHARMACEUTICAL USE |
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|
RU2807484C2 |
