FIELD: biotechnology.
SUBSTANCE: group of inventions relates to biotechnology and can be used in medicine. Invention discloses an anti-claudin antibody conjugate with at least one exatecan fragment (see compound of general formula (Pc-L-Y-D)), where Pc is an antibody to claudin 18.2 or its antigen-binding fragment, and L, Y and n are as defined in the present description.
EFFECT: invention can be used in preparing a drug for treating cancer, the cells of which are characterized by high expression of claudin 18.2.
31 cl, 16 ex, 17 tbl, 5 dwg
| Title |
Year |
Author |
Number |
| ANTI-CLAUDIN 18.2 ANTIBODY AND USE THEREOF |
2020 |
- Yan, Yan
- Ge, Khu
- Tao, Vejkan
|
RU2822550C2 |
| CONJUGATE OF TROP-2 ANTIBODY AND EXATECAN ANALOGUE AND MEDICAL USE THEREOF |
2021 |
- Yang Yang
- Hu Qiyue
- Tao Weikang
|
RU2830167C1 |
| ANTIBODY TO CD3 AND ITS PHARMACEUTICAL USE |
2019 |
- Ying Hua
- Zhang Ling
- Yang Xiaoying
- Ge Hu
- Tao Weikang
|
RU2802272C2 |
| CONJUGATE OF ANTI-CEA ANTIBODY AND EXCATECAN ANALOGUE AND PHARMACEUTICAL USE THEREOF |
2020 |
- Ying Hua
- Mao Langyong
- Wang Sijia
|
RU2833323C1 |
| PHARMACEUTICAL COMPOSITION BASED ON ANTIBODY TO PD-L1 AND ITS APPLICATION |
2018 |
- Yan, Zhen
- Yang, Jianjian
- Yan, Xiaodan
- Wu, Shan
- Liu, Xun
|
RU2766590C2 |
| CONNECTIVE TISSUE GROWTH FACTOR ANTIBODY AND USE THEREOF |
2020 |
- Fu, Yayuan
- Ma, Syaoli
- Ge, Khu
- Tao, Vejkan
|
RU2819228C2 |
| PHARMACEUTICAL COMPOSITION BASED ON ANTIBODIES AGAINST CD40 AND APPLICATION THEREOF |
2019 |
- Yang, Jianjian
- Li, Hao
- Liu, Xun
- Jiang, Jiahua
|
RU2778572C1 |
| PHARMACEUTICAL COMPOSITION CONTAINING ANTIBODIES TO PCSK-9, AND ITS USE |
2018 |
- Tian, Chenmin
- Li, Hao
- Liu, Xun
|
RU2782792C2 |
| ERIBULIN DERIVATIVE DRUG CONJUGATE, METHOD FOR PREPARATION THEREOF AND USE THEREOF IN MEDICINE |
2021 |
- Huang Jian
- Zhu Lingjian
- Yu Xiuzhao
- Zhu Bo
- Ren Wenming
- Tang Mi
- Sun Xing
- Yang Yang
- Liang Jindong
- Hu Qiyue
|
RU2830242C1 |
| ANTIBODY TO PD-1, ITS ANTIGEN-BINDING FRAGMENT AND ITS PHARMACEUTICAL USE |
2020 |
- Gu Xiaoling
- Ye Xin
- Ge Hu
- Tao Weikang
|
RU2807484C2 |
