CONJUGATE OF ANTI-CLAUDIN ANTIBODY AND MEDICINAL AGENT AND PHARMACEUTICAL USE THEREOF Russian patent published in 2024 - IPC C07K16/28 A61K47/68 A61K39/395 A61K31/4745 A61P35/00 

Abstract RU 2826119 C1

FIELD: biotechnology.

SUBSTANCE: group of inventions relates to biotechnology and can be used in medicine. Invention discloses an anti-claudin antibody conjugate with at least one exatecan fragment (see compound of general formula (Pc-L-Y-D)), where Pc is an antibody to claudin 18.2 or its antigen-binding fragment, and L, Y and n are as defined in the present description.

EFFECT: invention can be used in preparing a drug for treating cancer, the cells of which are characterized by high expression of claudin 18.2.

31 cl, 16 ex, 17 tbl, 5 dwg

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RU 2 826 119 C1

Authors

Yang Yang

Xu Jianyan

Tao Weikang

Dates

2024-09-04Published

2020-12-11Filed