PHARMACEUTICAL COMPOSITIONS WITH DEFERRED RELEASE CONTAINING VALPROIC ACID AND THEIR USE Russian patent published in 2021 - IPC A61K31/194 A61K31/20 A61K9/28 A61P7/02 A61P9/10 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to the field of pharmaceutics, namely to a pharmaceutical composition for achieving a decrease in PAI-1 level in plasma and to the use of a pharmaceutical composition for the treatment or prevention of a pathological condition associated with excessive fibrin deposition and/or the blood clot formation. The pharmaceutical composition has one or more solid nuclei containing: valproic acid and/or its pharmaceutically acceptable salt in the amount of at least 50% of the core weight, one or more additional acid selected from succinic acid and fumaric acid in the amount from 0.1% to 3% of the weight of VA and/or its pharmaceutically acceptable salt in the corresponding solid core and, optionally, one or more pharmaceutically acceptable excipient.

EFFECT: group of inventions provides for the creation and use of a pharmaceutical composition containing valproic acid and/or its pharmaceutically acceptable salt, in which a deferred release of active ingredients is provided, which allows levels of valproic acid in plasma and/or its pharmaceutically acceptable salts, and/or its metabolites, to coincide with peak levels of PAI-1 in plasma, which, in turn, provides treatment or prevention of diseases associated with excessive fibrin deposition and/or the blood clot formation.

14 cl, 7 dwg, 11 tbl, 13 ex