SALT AND POLYMORPH OF A PHENYL-PYRIMIDONE COMPOUND, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF Russian patent published in 2021 - IPC C07D239/32 C07D239/36 A61K31/506 

Abstract RU 2761213 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a method for producing a compound by the formula (1): . The method includes adding the compound Z to alcohol, adding hydrochloric acid, heating at a temperature from 60 to 70°C, additionally adding activated carbon to discolour, adding an ester to the resulting filtrate, settling or mixing, followed by separating the precipitated solid, resulting in the above compound, wherein compound Z has the following structural formula: . Also proposed are variants of the method for producing the compound by the formula (1).

EFFECT: implementation of a new method for producing a compound by the formula (1), exhibiting stable properties and low hygroscopicity.

4 cl, 11 dwg, 6 tbl, 16 ex

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RU 2 761 213 C2

Authors

Shen, Jingshan

He, Yang

Chen, Weiming

Li, Jianfeng

Tian, Guanghui

Gong, Xudong

Wang, Zhen

Zhang, Rongxia

Liu, Yongjian

Jiang, Hualiang

Dates

2021-12-06Published

2018-07-02Filed