TRIAZOLPYRIMIDINE COMPOUNDS AND THEIR USE IN TREATMENT OF CANCER Russian patent published in 2023 - IPC C07D487/04 A61K31/519 A61K31/5377 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates specifically to compounds with formula (I) and their pharmaceutically acceptable salts that selectively inhibit MCT4 (monocarboxylate transporter 4), pharmaceutical compositions based thereon, their use for obtaining a drug and a method for treating MCT4-mediated cancer.

EFFECT: development of compounds that selectively inhibit MCT4 (monocarboxylate transporter 4). In general formula (I), R¹ and R² are each independently hydrogen or methyl; X is CH₂ or O; each ring A and ring B is independently a ring selected from phenyl, pyridinyl, pyrazinyl, pyrimidinyl and pyridazinyl, where each ring A and ring B is independently optionally substituted with one or more substituents selected from C_1-3 alkyl and C_{1 -3} alkoxy; ring C is a 5-9 membered monocyclic or bicyclic saturated heterocycloalkyl optionally containing one or more additional heteroatoms independently selected from O, N and S, where ring C is optionally substituted with one or more substituents selected from C_1-3 alkyl optionally substituted with methoxy or hydroxyl; dioxo, C_0-2 alkyl-C(O)N(Me)₂, C(O)C_1-2 alkyl and S(O)₂C_1-2 alkyl.

23 cl, 5 dwg, 3 tbl, 87 ex