FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to a heterocyclic compound of the formula (I) or its pharmaceutically acceptable salt, where R1 is -CH3, -CF3, -CH2CH3, -CH2F, CF2CH2OH, -CHF2, -CH=CH2, -CH2OH or phenyl; R2 is -H, -CH2OH or -CH3; R3 is -H, or R2 и R3 taken together form cyclopropyl with carbon, to which they are attached; R4 is -H, -F or -CH3; R5 is -C(O)OH, -C(O)OCH3, -CH2C(O)OH, cyclopropyl, -C(O)NHCN, or
; where R6 is phenyl, -CH3, cyclopropyl,
or
; n is equal to 0-1; m is equal to 1-2; R7 is -H, -CH3 or is absent, when n is equal to 0; R8 is -CF3, -H, -Cl, -F, -CH2CH3, -OCH3, -CH3, -SCH3, -CH2OH, -CH2F, -CH2Cl, -I, -Br, -NH2, -CH2OCH2CH2F, -OCH2CH2F, -CH2CH2CH2F, -OCF3, -OH, -N(CH3)2, -CF2CH2OH or
, or a bound connecting R8 and ring A is a double bound, and R8 is CH2; R9 is -H, -Cl or -CF3; R10 is -H, -CH3, -CH2F, -CH2OH or -CH2OCH2-phenyl; X1 and X2 are either C, or one of them is C, and the other one is N;
is a single bound or a double bound, and ring A is phenyl or cyclohexyl. The invention also relates to a pharmaceutical composition based on it.
EFFECT: new heterocyclic compounds are obtained having antagonistic activity relatively to E prostaglandin 4 receptor (EP4).
29 cl, 5 dwg, 1 tbl, 104 ex
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Authors
Dates
2021-12-07—Published
2016-10-14—Filed