FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein D is -C(Rd1)(Rd2) - or -N(Rd4) -; R1 is selected from the group consisting of H, C1-3alkyl, C1-3alkyloxy, benzyloxy and , in which R101 is selected from the group consisting of H, methyl, ethyl, n-propyl or isopropyl; R3 is selected from the group consisting of H, F, Cl, Br; R2 satisfies any of the following requirements (1)–(10): (1) R2 is selected from H or CN; (2) R2 is -CH2N (R201) (R202), in which R201 and R202 are separately and independently selected from the group consisting of H, C1-3alkyl, C1-3alkylacyl or C3-6cycloalkylacyl; (3) R2 is represented by heterocyclic structures denoted by groups (3a) and (3b); (4) R2 is represented by structure (4a); (5) R2 is represented by structure 5a; (6) R2 is represented by a structure comprising (6a) or (6b); (7) R2 is represented by structure (7a); (8) R2 is represented by structure (8a); (9) R2 is represented by structure (9a); (10) R2 is represented by structure (10a), in which T22 is selected from the group consisting of N or C (R224); Rd1 and Rd2 are separately and independently selected from the group consisting of H, F, Cl, Br, I, OH; Rd4 is selected from the group consisting of H and R03; R03 is C1-10alkyl; R03 is optionally substituted with R001; R001 is selected from the group consisting of F, Cl, Br, I, OH, N(CH3)2, NH(CH3), NH2, and CH3O; and the number R001 is selected from 0, 1, 2 and 3.
табл., 129 пр.
,
(3а),
and (3b),
(4а), (5а), (6а)
and
(6b), (7a), (8a),
(9a), (10a).
EFFECT: compounds of the invention are intended for the treatment of cancer.
15 cl, 1 tbl, 129 ex
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Authors
Dates
2018-11-19—Published
2015-03-30—Filed