ANALOGUES OF 4H-PYRAZOLO[1,5-A]BENZIMIDAZOLE COMPOUNDS AS PARP INHIBITORS Russian patent published in 2018 - IPC C07D487/04 C07D519/00 A61P35/00 A61P25/00 A61P9/10 A61P29/00 A61P3/10 

Abstract RU 2672722 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein D is -C(Rd1)(Rd2) - or -N(Rd4) -; R1 is selected from the group consisting of H, C1-3alkyl, C1-3alkyloxy, benzyloxy and , in which R101 is selected from the group consisting of H, methyl, ethyl, n-propyl or isopropyl; R3 is selected from the group consisting of H, F, Cl, Br; R2 satisfies any of the following requirements (1)–(10): (1) R2 is selected from H or CN; (2) R2 is -CH2N (R201) (R202), in which R201 and R202 are separately and independently selected from the group consisting of H, C1-3alkyl, C1-3alkylacyl or C3-6cycloalkylacyl; (3) R2 is represented by heterocyclic structures denoted by groups (3a) and (3b); (4) R2 is represented by structure (4a); (5) R2 is represented by structure 5a; (6) R2 is represented by a structure comprising (6a) or (6b); (7) R2 is represented by structure (7a); (8) R2 is represented by structure (8a); (9) R2 is represented by structure (9a); (10) R2 is represented by structure (10a), in which T22 is selected from the group consisting of N or C (R224); Rd1 and Rd2 are separately and independently selected from the group consisting of H, F, Cl, Br, I, OH; Rd4 is selected from the group consisting of H and R03; R03 is C1-10alkyl; R03 is optionally substituted with R001; R001 is selected from the group consisting of F, Cl, Br, I, OH, N(CH3)2, NH(CH3), NH2, and CH3O; and the number R001 is selected from 0, 1, 2 and 3.

табл., 129 пр.

,

(3а),

and (3b),

(4а), (5а), (6а)

and

(6b), (7a), (8a),

(9a), (10a).

EFFECT: compounds of the invention are intended for the treatment of cancer.

15 cl, 1 tbl, 129 ex

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RU 2 672 722 C2

Authors

Van Syuekhaj

Din Chzhaochzhun

Syuj Yun

Chen Shukhuej

Li Le

Li Gan

Tu Zhunkhua

Van Tsajlin

Yue Yan

Chzhan Chzhibo

Chen Khajlyan

Sun Ventsze

Khuan Lu

Dates

2018-11-19Published

2015-03-30Filed