ANALOGUES OF 4H-PYRAZOLO[1,5-A]BENZIMIDAZOLE COMPOUNDS AS PARP INHIBITORS Russian patent published in 2018 - IPC C07D487/04 C07D519/00 A61P35/00 A61P25/00 A61P9/10 A61P29/00 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein D is -C(R_d1)(R_d2) - or -N(R_d4) -; R₁ is selected from the group consisting of H, C_1-3alkyl, C_1-3alkyloxy, benzyloxy and , in which R₁₀₁ is selected from the group consisting of H, methyl, ethyl, n-propyl or isopropyl; R₃ is selected from the group consisting of H, F, Cl, Br; R₂ satisfies any of the following requirements (1)–(10): (1) R₂ is selected from H or CN; (2) R₂ is -CH₂N (R₂₀₁) (R₂₀₂), in which R₂₀₁ and R₂₀₂ are separately and independently selected from the group consisting of H, C_1-3alkyl, C_1-3alkylacyl or C_3-6cycloalkylacyl; (3) R₂ is represented by heterocyclic structures denoted by groups (3a) and (3b); (4) R₂ is represented by structure (4a); (5) R₂ is represented by structure 5a; (6) R₂ is represented by a structure comprising (6a) or (6b); (7) R₂ is represented by structure (7a); (8) R₂ is represented by structure (8a); (9) R₂ is represented by structure (9a); (10) R₂ is represented by structure (10a), in which T₂₂ is selected from the group consisting of N or C (R₂₂₄); R_d1 and R_d2 are separately and independently selected from the group consisting of H, F, Cl, Br, I, OH; R_d4 is selected from the group consisting of H and R₀₃; R₀₃ is C_1-10alkyl; R₀₃ is optionally substituted with R₀₀₁; R₀₀₁ is selected from the group consisting of F, Cl, Br, I, OH, N(CH₃)₂, NH(CH₃), NH₂, and CH₃O; and the number R₀₀₁ is selected from 0, 1, 2 and 3.

табл., 129 пр.

,

(3а),

and (3b),

(4а), (5а), (6а)

and

(6b), (7a), (8a),

(9a), (10a).

EFFECT: compounds of the invention are intended for the treatment of cancer.

15 cl, 1 tbl, 129 ex