METHOD FOR CHOOSING THE TACTICS OF RADIATION THERAPY IN PATIENTS WITH MALIGNANT GLIOMAS Russian patent published in 2022 - IPC A61N5/10 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely oncology, and can be used when choosing the tactics of radiation therapy in patients with malignant gliomas. The method includes determination of hemostasis parameters, determination of the D-dimer value in blood serum, selection of the fractionation mode of postoperative radiation therapy. Additionally, the growth rate of a fibrin clot is determined and the formation of spontaneous clots is detected, and if the blood D-dimer level is fixed at ≤2 mcg/ml, the growth rate of a fibrin clot is ≤29 microns/min, the absence of spontaneous clot formation, a course of radiation therapy is prescribed in the mode of single focal dose-2 Gy to total focal dose-60 Gy. If the blood D-dimer level is fixed at >2 mcg/ml, the growth rate of a fibrin clot is >29 microns/min and there is no formation of spontaneous clots, radiation therapy is prescribed in the mode of SFD-2.5 Gy to TFD 60 Gy. If the blood D-dimer level is fixed >2 mcg/ml, the fibrin clot growth rate >29 microns/min and there is the formation of spontaneous fibrin clots, a split course of radiation therapy is prescribed in the mode of SFD-3 Gy to TFD-60 Gy with a break of 2 weeks for SFD 30 Gy.

EFFECT: use of the invention makes it possible to prescribe postoperative radiation therapy for malignant glioma of the brain, regardless of age, in a mode that provides the highest effectiveness of this type of treatment, taking into account the degree of hypoxia in the zone of residual glioblastoma that occurs in response to hypercoagulation followed by thrombosis in the vessels of the microcirculatory bed located in the bed of the resected tumor, to increase the life expectancy of this category of patients.

1 cl, 4 ex