METHOD FOR ASSESSING THE CYTOPROTECTIVE EFFECT OF IMMUNOGLOBULIN PREPARATIONS FOR INTRAVENOUS INTRODUCTION ON TROPHOBLAST CELLS UNDER CONDITIONS OF THEIR INTERACTION WITH NATURAL KILLERS Russian patent published in 2022 - IPC G01N33/48 C12N5/73 C12N5/783 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine. A method for evaluating the cytoprotective effect (CPE) of intravenous immunoglobulin preparations (IVIGP) against trophoblast cells under conditions of their interaction with natural killers is proposed. A culture of trophoblast cells is used, some of which are incubated without mononuclear cells, some in the presence of monoculars, and some in the presence of IVIGP preparation at a concentration of 6 mg/ml. The number of non-viable trophoblast cells is determined. The coefficient of the cytoprotective effect of IVIGP preparations in relation to trophoblast cells is calculated. With CPE <1, a positive cytoprotective effect is predicted. With CPE ≥1, there is no cytoprotective effect.

EFFECT: invention allows evaluating the effectiveness of CPE of IVIGP preparation in relation to trophoblast cells in vitro in the presence of peripheral blood NK cells.

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