METHOD OF TREATING CANCER USING A COMBINATION OF DNA DAMAGING AGENTS AND ATR INHIBITORS Russian patent published in 2022 - IPC A61K45/06 A61K31/497 A61K31/7048 A61K31/7068 A61P35/00 A61N5/10 

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to the use of a compound of formula A-2, which inhibits ATP-protein kinase, or a pharmaceutically acceptable salt thereof for the treatment of a proliferative disorder in a subject, selected from non-small cell lung cancer, breast cancer, colon and rectal cancer and ovarian cancer. Application involves administering to a subject in need thereof a DNA damaging agent selected from cisplatin and carboplatin, and then a compound, which inhibits ATP-protein kinase — compound A-2 or its pharmaceutically acceptable salt. Modes of introducing a platinising agent and a compound which inhibits ATP-protein kinase are disclosed in the claim.

EFFECT: group of inventions provides a synergistic action due to the use of cisplatin or carboplatin and a compound A-2 / a pharmaceutically acceptable salt thereof, in the treatment of non-small cell lung cancer, breast cancer, colon and rectal cancer and ovarian cancer; group of inventions also allows reducing side effects in treating said types of cancer, in particular leads to reduced toxicity with respect to healthy cells.

24 cl, 17 dwg, 6 tbl, 9 ex