NEW HIF-1-ALPHA INHIBITOR, METHOD FOR PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ANGIOGENESIS-ASSOCIATED EYE DISEASES, CONTAINING SAID INHIBITOR AS AN ACTIVE COMPONENT Russian patent published in 2022 - IPC C07C49/84 C07C225/22 C07D207/06 C07D211/08 C07D265/30 A61K31/12 A61K31/136 A61K31/40 A61K31/451 A61K31/5375 A61P27/02 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound represented by the following Formula (1), used for treating or preventing age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, or a neovascular glaucoma, to a pharmaceutical composition containing said compound, and to a method for treating or preventing age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, or a neovascular glaucoma using said compound.

.

In Formula 1, A¹ and A², each independently, are -H, halogen or methoxy; B¹ is -H or methoxy; R¹ is C_3-10cycloalkyloxy, heterocycloalkyl with a 5- or 6-membered ring, containing at least one heteroatom selected from the group consisting of N, O and S, or benzylamino; wherein the benzyl group can optionally be replaced by at least one -CN.

EFFECT: provided compound for preventing or treating angiogenesis-associated eye diseases.

6 cl, 3 dwg, 2 tbl, 21 ex