FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically, to recombinant antigens of human desmoglein, and can be used in clinical laboratory diagnostics of pemphigus vulgaris.
EFFECT: invention makes it possible to determine the antigenic specificity of autoreactive antibodies to individual fragments of the extracellular domain of human desmoglein-3 in patients with pemphigus vulgaris by applying a recombinant antigen protein containing antigen proteins of the extracellular domain of human desmoglein-3 and fragments thereof with sequences SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11, respectively.
3 cl, 4 dwg, 1 tbl, 3 ex
| Title | Year | Author | Number |
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