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2 771 383

(13)

(51)

IPC

C12N9/22(2006-01-01)

C12N15/55(2006-01-01)

C12N15/63(2006-01-01)

C12N15/90(2006-01-01)

A61K48/00(2006-01-01)

(21) (22)

Application

2018142174, 2017-06-02

(24)

Start date

2017-06-02

(22)

Actual filing date

2017-06-02

(45)

Published

2022-05-04

(72)

Inventor

Ravassard PhilippeMallet JacquesSerguera Che

(73)

Holder

Inserm National De La Sante Et De La Recherche Medicale)Icm Du Cerveau Et De La Moelle Epiniere)Centre National De La Recherche ScientifiqueSorbonne UniversiteCommissariat A L'Energie Atomique Et Aux Energies AlternativesAssistance Publique Hopitaux De Paris

FOOD RATION-CONTROLLED EXPRESSION OF NUCLEIC ACID ENCODING Cas9 NUCLEASE, AND ITS APPLICATIONS Russian patent published in 2022 - IPC C12N9/22 C12N15/55 C12N15/63 C12N15/90 A61K48/00

Abstract RU 2771383 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular to nucleic acid containing regulatory polynucleotide containing minimal promotor and from one to twenty of AARE (amino acid response element) nucleic acids, and nucleic acid encoding Cas nuclease that is under control of the specified regulatory polynucleotide. The invention also relates to a vector, a particle, a cell and a composition containing the above-mentioned nucleic acid, and a method for genome editing using the specified composition.

EFFECT: invention is effective for controlled expression of nucleic acid encoding Cas nuclease in at least one target cell in an individual.

13 cl, 7 dwg, 1 tbl, 2 ex

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RU 2 771 383 C2

Authors

Ravassard Philippe

Mallet Jacques

Serguera Che

Dates

2022-05-04—Published

2017-06-02—Filed