PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINEAMIDE COMPOUND Russian patent published in 2022 - IPC C07D207/16 C07D401/10 C07D403/10 A61K31/4439 A61K31/496 A61P13/12 A61P37/08 A61P37/06 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of the formula (I) or its pharmaceutically acceptable salt, where, in the formula, R¹ is lower alkyl or halogen lower alkyl, R² is halogen or halogen lower alkyl, L is a bond or -CH₂-, A is CH or N, R³ is H or lower alkyl, R⁴ and R⁵ are the same or different and are H or lower alkyl, R⁶ and R⁷ are the same or different and are H, lower alkyl or halogen. The invention also relates to a pharmaceutical composition for the prevention or treatment of an autoimmune disease by means of inhibiting cathepsin S, containing the effective amount of a compound or its pharmaceutically acceptable salt of the compound of the formula I and one or several auxiliary substances. Compounds of the formula I are intended for the prevention or treatment of an autoimmune disease by means of inhibiting cathepsin S, wherein the autoimmune disease is selected from SLE and lupus nephritis, allergies or organ, bone marrow or tissue transplant rejections.

EFFECT: phenyldifluoromethyl-substituted prolineamide compound is obtained, inhibiting cathepsin S.

24 cl, 24 tbl, 18 ex