FIELD: pharmacology.
SUBSTANCE: invention relates to a compound of formula
,
where one of A1 and A2 is -NR9-, and the other is -CH2-; R1 is halogen; R2 is hydrogen; R3 is hydrogen, halogen; R4 and R5 together with the carbon atom to which they are attached form C3-C6-cycloalkyl; R6 is halogen; R7 is hydrogen; R8 is hydrogen, halogen, C1-C6-alkoxy, halo-C1-C6-alkoxy or substituted heterocyclyl, wherein the heterocyclyl is pyridinyl, pyrazolyl, wherein the substituted heterocyclyl is heterocyclyl substituted with one to three substituents independently selected from C1-C6-alkyl; and R9 is hydrogen, C1-C6-alkyl, halo-C1-C6-alkyl, formyl or C1-C6-alkoxycarbonyl.
EFFECT: compounds have cathepsin S or L cysteine protease inhibitor activity and can be used to treat or prevent diseases associated with cathepsin S or L cysteine protease.
15 cl, 1 tbl, 53 ex
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