METHOD FOR TREATING PROLIFERATIVE VITREORETINOPATHY USING LIPOSOME-ASSOCIATED MELPHALAN IN AN EXPERIMENT Russian patent published in 2022 - IPC A61F9/07 A61P27/02 A61K31/13 

Abstract RU 2772520 C1

FIELD: medicine.

SUBSTANCE: invention relates to ophthalmology and is intended for treating proliferative vitreoretinopathy in an experiment using liposome-associated melphalan. The medicinal product melphalan 0.0025 mg is administered once intravitreally in a volume of 0.1 ml. Melphalan is therein used as a lipophilic prodrug, diglyceride ester conjugate in the composition of a stealth liposomal form - pegylated form with a modified nanoparticle size of 500 nm.

EFFECT: method minimises the retinotoxic effect of melphalan.

1 cl, 2 ex, 2 dwg

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Authors

Leparskaya Nataliya Leontinovna

Khoroshilova Inna Petrovna

Vodovozova Elena Lvovna

Kaplun Aleksandr Petrovich

Alekseeva Anna Sergeevna

Tretyakova Darya Sergeevna

Dates

2022-05-23Published

2021-07-05Filed