FIELD: medicine.
SUBSTANCE: invention relates to ophthalmology and is intended for treating proliferative vitreoretinopathy in an experiment using liposome-associated melphalan. The medicinal product melphalan 0.0025 mg is administered once intravitreally in a volume of 0.1 ml. Melphalan is therein used as a lipophilic prodrug, diglyceride ester conjugate in the composition of a stealth liposomal form - pegylated form with a modified nanoparticle size of 500 nm.
EFFECT: method minimises the retinotoxic effect of melphalan.
1 cl, 2 ex, 2 dwg
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Authors
Dates
2022-05-23—Published
2021-07-05—Filed