FIELD: biotechnology.
SUBSTANCE: monoclonal antibody or its antigen-binding fragment that bind to human β-Clotho are proposed. Nucleic acids encoding the specified antibody, an expression vector, and a host cell that are used in an antibody production method are also proposed. In addition, pharmaceutical compositions and methods for a decrease in body weight, reduction in appetite or food consumption, reduction in TG concentration in blood plasma or TC concentration in blood plasma in an individual, treatment of a metabolic FGF21-associated disorder, atherosclerosis, peripheral arterial disease, stroke, heart failure or coronary heart disease are presented.
EFFECT: invention provides for the activation of a receptor complex of the human fibroblast growth factor 21 (hereinafter – FGF21) and FGF21-mediated signal transmission using FGF21 mimetic antibodies with improved stability characteristics.
29 cl, 11 dwg, 4 tbl, 6 ex
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